Journal: Heliyon

Article Title: Dopamine D2 receptor activation counteracts olfactory dysfunction and related cellular abnormalities in experimental parkinsonism

doi: 10.1016/j.heliyon.2024.e35948

Figure Lengend Snippet: Chronic pramipexole treatment rescues olfactory discrimination in a mouse model of PD. (A) Schematic representation of the experimental design, including the habituation-dishabituation behavioral test performed in mice with a sham lesion (Control), a 6-OHDA lesion (6-OHDA) and a 6-OHDA lesion followed by administration of pramipexole (6-OHDA + PPX). (B, C) Bar graphs showing (B) distance traveled during the olfactory test and (C) total time spent exploring the odors. **p < 0.01 and ***p < 0.001 vs. Control, one-way ANOVA followed by Bonferroni post-hoc test, (B) F 2, 22 = 12.23 and (C) F 2, 22 = 7.2. (D–F) Line graphs showing the time (s) spent by Control, 6-OHDA, and 6-OHDA + PPX mice exploring saline or the three social odors from distinct pools of female (Female 1 and Female 2) and male (Male) mice. *p < 0.05, **p < 0.01, ***p < 0.001 vs. dishabituation time, and #p < 0.05, ##p < 0.01, ###p < 0.001 vs. habituation time; Brown-Forsythe ANOVA followed by Welch post-hoc test, F 6, 13 = 24.1 for (D), F 6, 26 = 37.3 for (E), and F 6, 27 = 8.3 for (F).

Article Snippet: Pramipexole dihydrochloride (MedChemExpress, Monmouth Junction, USA) was administered in the drinking water for four weeks following sham- or 6-OHDA-lesion and prior to behavioral experiments.

Techniques: Control, Saline